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That distinction is not a technicality

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Takahashi et al., 2023)

Calcium, diacylglycerol, cAMP and various phosphate derivatives of myoinositol (phosphatidylinositol and others) are essential secondary messengers involved in the regulation of intracellular signaling cascades, in response to the activation of the TSHR, and are necessary for the production H 2 O 2 and TG synthesis (56)