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Orally administered CGA undergoes hydrolysis by intestinal and hepatic esterases, generating caffeic acid that is further subjected to methylation, glucuronidation, and sulfation before renal excretion

The Action to Control Cardiovascular Risk in Diabetes trial and the Veterans Affairs Diabetes Trial have shown that while intensive glycemic control may slow the progression of neuropathy, it does not significantly prevent its onset

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[DOI] [PubMed] [Google Scholar] 27.Klein EA, Thompson IM, Jr, Tangen CM, et al

Arrows indicate stimulation (green), inhibition (blue), and the resulting cardiovascular effects (red)