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Deshpande V, Zen Y, Chan JK, et al

However, this method may induce denaturation in the therapeutic peptides due to exposure to organic solvents and sonication parameters, and is suitable only for molecules with high molecular weight

Gastrointestinal side effects (nausea, vomiting, diarrhea) were the most common, and most were mild to moderate

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Proteomics Clin Applications (2018) 12(1)