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**Enhances thermogenesis** -- you produce more body heat, which requires caloric energy Published data from the Phase 2 trial showed measurable increases in metabolic rate among retatrutide participants that were not observed in the placebo group or in comparable semaglutide/tirzepatide trials

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Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial