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RNA sequencing Sequencing libraries were generated using the NEBNext UltraTM RNA Library Prep Kit for Illumina following the manufacturers recommendations, and index codes were added to attribute sequences to each sample

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Results Atorvastatin triggers opening of RyR1 We solved cryo-EM structures of rabbit RyR1 in activating conditions (Ca 2+ and caffeine) and in the presence of atorvastatin (Fig

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