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For patients with severe obesity (BMI 40 or 35 with obesity-related complications), referral for evaluation of bariatric surgery may be appropriate according to American Society for Metabolic and Bariatric Surgery guidelines
![glp-1 GLP-1 GLP-1 | YBC[]](https://ybc-beauty.com/wp-content/uploads/2023/02/GLP1-1024x616.png)
These can often be managed by eating slowly, having smaller portions, and staying well hydrated
![glp-1 GLP-1 GLP-1 | YBC[]](https://ningyocho-cl.com/diet/wp-content/uploads/2026/03/glp1-diet-rebound-rate-mounjaro-comparison.png)
Cummings: There are a lot of hints that the drugs may act in the reward centers of the brain, and those actions may have something to do with why they seem to be associated with lower alcohol and substance abuse and smoking, and other compulsive behaviors like gambling and shopping
![glp-1 GLP-1 GLP-1 | YBC[]](https://march-clinic.com/wp-content/uploads/GLP-1%E3%81%A7%E3%83%AA%E3%83%90%E3%82%A6%E3%83%B3%E3%83%89%E3%81%99%E3%82%8B%E5%8E%9F%E5%9B%A0.png)
Although there are some experimental skin patches where GLP-1 agonist medicines like semaglutide are used as active ingredients, these are still under trial and not yet approved for use
![glp-1 GLP-1 GLP-1 | YBC[]](https://private-clinic-ebisu.com/wp-content/uploads/2020/04/%E3%83%80%E3%82%A4%E3%82%A8%E3%83%83%E3%83%88.jpeg)
What is Core+
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