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Genetic evidence underscores the pathway's importance: humans with loss-of-function MC4R mutations develop severe early-onset obesity (prevalence approximately 2.5% of morbidly obese populations), hyperphagia, and insulin resistance

The disclosure also provides kits for preventing, treating or ameliorating the symptoms of a diseases or disorder in a mammal described herein

In the Bridge Program: What Medications Are Included

Therefore, there is a pressing need to explore more efficient methods for target discovery, such as AI-driven technologies, to comprehensively analyze Chinese medicine compound prescriptions and systematically identify novel drug targets