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Hess and colleagues have recently demonstrated that both mice with TNF--mediated arthritis and humans with RA show enhanced brain activity in the centers involved in pain perception and the control of emotions [77]

In summary, obesity leads to decreased mitochondrial function and increased insulin resistance

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Early real-world data suggest promising results in post-bariatric patients, though formal trials are limited

Chen, Z., Liu, J., Wang, A., Wu, B., Cheng, Z., Jiang, Y., Gu, H., Ding, L., Mo, J., Jiang, Y., Liu, L., Jing, L., Jing, J., Wang, Y., Zhao, X., Wang, Y., Qin, H., & Li, Z