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Gene and protein delivery platforms Nanocarrier-enabled delivery of macromolecules, including genes, small interfering RNAs (siRNAs), and proteins, represents a paradigm shift in GLP-1R-targeted therapy, providing prolonged or programmable effects that outperform conventional small-molecule approaches in duration, precision, and disease specificity [213, 425, 426]

This weeks column is by the UK College of Pharmacy Chief Practice Officer Brooke Hudspeth, Pharm.D

However, most of these studies were done with liraglutide or other daily GLP-1RA, which are not as effective for weight loss as the newer GLP-1RA (e.g., semaglutide or tirzepatide)