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dose reduction of concomitant medications may be necessary Diabetic retinopathy: Rapid improvement in glycemic control has been associated with temporary worsening of diabetic retinopathy in some diabetes trials Acute kidney injury: Cases have been reported, often in the setting of volume depletion from gastrointestinal adverse effects Gallbladder disease: Risk of cholelithiasis and cholecystitis may be increased Hypersensitivity reactions: Including anaphylaxis and angioedema have been reported Not recommended: In patients with severe gastrointestinal disease, including severe gastroparesis Additional important counseling points: Pregnancy: Zepbound should not be used for weight management during pregnancy

The Intestine as a Primary Reward Sensor A major conceptual shift is recognizing the gastrointestinal tract functions as a sensory organ for reward

Over time, though, as your body acclimates to intense exercise, you may start releasing less

But it's better to have loved and lost than to have never loved at all, as they say