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Given cryo-EM structures of the GLP-1R in complex with G s are stabilised by trapping the nucleotide-free G protein on the ligand-activated receptor, it is not surprising that the G s interactions are similar across the four structures, even when bound by different agonists, nonetheless the MD simulations revealed potential differences in the dynamics of these interactions

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Metabolomic data analysis We measured the concentrations of 54 metabolites and also evaluated the ratios of these metabolites (Supplementary Table 1)

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Limited Safety Data There is minimal data on semaglutide levels in human breast milk or its effects on breastfed infants