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This niacinamide-containing serum can be applied to underarms to treat discoloration, though it would be wise to do a test spot first before applying it more liberally, he advises

However, a comprehensive review published in 2025 emphasized that the majority of this evidence remains preclinical , meaning it was not conducted in large, well-controlled human trials

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The big difference here is that cancer research, for example, deals with end of life situations, and any such research can take on higher risks than when dealing with perfectly healthy subjects

Suitability: Good for widespread, superficial freckles and overall sun damage