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"The adverse effect observed may be causal or may be because semaglutide is offered to people already at higher risk of ION, that is," Adler said

With metabolic stress, leukocyteendothelial interactions become more adhesive and pro-inflammatory, contributing to endothelial dysfunction, vascular stiffness, and atherosclerotic progression

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines (Higgins and Green, 2008)

Next-generation oral candidates like orforglipron promise improved bioavailability and dosing flexibility without requiring special storage conditions or meal timing [2]

& Rowena Mathews, G