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For example, administration of metformin (1000 mg) via a nasoluminal catheter into the ileum, a region of the gut that is rich in L cells did not elicit any GLP-1 response over a 1 h period in patients with type 2 diabetes [8]

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In study 1, the average weight loss at one year was about: 2.1 percent of baseline body weight in the placebo group 6.7 percent of baseline body weight in the lower-dose group (3.75 milligrams [mg] phentermine/23 mg topiramate) 14.4 percent of baseline body weight in the higher-dose group (15 mg phentermine/92 mg topiramate) In study 2, the average weight loss at one year was about: 1.2 percent of baseline body weight in the placebo group 7.8 percent in the lower-dose group (7.5 mg phentermine/46 mg topiramate) 9.8 percent of baseline body weight in the higher-dose group (15 mg phentermine/92 mg topiramate) At one year, a greater proportion of participants in both trials lost 5 to 10 percent of their body weight compared with those in the placebo groups

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Therefore, we used metformin as a control for the secondary analysis