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Additionally, the increase in the density of SynTom inputs to the PVH of GCG-Cre-SynTom::Lep ob/ob mice did not appear to be associated with any changes in the density or distribution of PPG neurons (Figure 3JL), suggesting that leptin impacts targeting of axons to the PVH, but does not alter PPG neuron number

This makes it harder for your cells to deal with oxidants and toxins

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This is often accompanied by nausea and vomiting