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10.1016/j.freeradbiomed.2015.06.011 213 PacherP.NivorozhkinA.SzabC

Due to its relatively short half-life, many research protocols split the total daily dose into two smaller administrations (e.g., morning and evening)

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When you run it indefinitely, you progressively reduce your own receptor sensitivity and the compound stops working while you're still paying for it

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