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Author Contributions L Nel: data curation, formal analysis, validation, investigation, visualization, methodology, project administration, and writingoriginal draft, review, and editing

Injection site reactions are the most common skin-related side effects, presenting as localized redness, swelling, bruising, or itching at the injection site

Akero sparked excitement earlier this year with Phase 2 data showing its drug reversed cirrhosis in patients who had reached the most severe stage of MASH

GLP-1 medications became popular because they can affect hunger, fullness, digestion, cravings, and blood sugar signaling in a more direct medical way

seek emergency care for hives, facial/tongue swelling, or difficulty breathing More serious potential adverse effects requiring immediate medical attention include signs of pancreatitis (severe abdominal pain radiating to the back, persistent nausea and vomiting), symptoms of gallbladder disease (right upper abdominal pain, jaundice, fever), signs of kidney problems (decreased urination, swelling, unusual fatigue), or symptoms of hypoglycemia (shakiness, confusion, rapid heartbeat, sweating) particularly when used with insulin or insulin secretagogues