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Others feel vulnerable and exposed in a smaller body, particularly if they used their weight as emotional armor

Putting the trial numbers into perspective Historically, anti-obesity drugs produced average weight losses in the single digits (510%), and even the best options rarely approached double-digit percentages at the population level

This increase in the number GLP-1-positive cells observed in mice was attributed to improved L cell differentiation and, furthermore, SCFAs were sufficient to increase L cell numbers in intestinal organoids of human and murine origin (25, 26)

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Una recente meta-analisi, che ha valutato lefficacia e la sicurezza della terapia con gli agonisti del GLP-1, ha osservato che quelli long-acting riducono pi efficacemente lemoglobina glicata (HbA1c) e la glicemia a digiuno rispetto agli short-acting e possono, quindi, essere usati anche in monoterapia