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At the low doses of nitroglycerin used to treat angina pectoris (cardiac pain associated with ischemic heart disease) there is a greater effect of vasodilation in veins compared to arteries which in turn reduces the volume of blood returning to the heart (venous return is referred to as preload)

Animal Model:Male A/J mice, lung carcinogenesis model [2] Dosage:1.3, 20.7, or 481 g/L Administration:Inhalation exposure, 45 min daily for 2 weeks Result:Reduced the tumor multiplicity

Vomiting occurred in 20% to 21% of participants

Because IGF-1 signalling promotes cell proliferation, a recognized theoretical concern is that it could promote the growth of existing tumors , and excess dosing can cause hypoglycemia

With consistent follow-through, patients often lose 5% to 15% of their starting body weight within 3 to 6 months