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Metabolism plays a key role in the origin or progression of many diseases, including neurodegenerative diseases, diabetes, and cancer [14]

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The second group comprises non-glutathione disulfide substrates (RS 2 or RSSR) that are reduced by two molecules of GSH, yielding one dithiol product or two monothiol products (R(SH) 2 or RSH + RSH) and GSSG (Fig