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Notably, despite the upregulation of SOD1 in the high-ROS subgroup of ErbB2-positive breast cancer cells, normal cellular proliferation still relies on SOD1 activity, indicating its dual role in promoting cancer progression and maintaining basal metabolism [22]
We demonstrated that the in vitro kidney organoid model enabled the identification of a novel mechanism that may be used for the treatment of Fabry disease
In this multicenter study conducted across 22 countries, participants (67.6% females and 72% White) received once-weekly subcutaneous administration of CagriSema ( n = 2,108) with dose escalation from 0.25 mg to a maximum of 2.4 mg for each drug, in addition to lifestyle intervention, compared with placebo ( n = 705)
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