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Figure 1 4.1.1 Cardiovascular outcomes in SGLT2 inhibitors: safety studies The EMPA-REG OUTCOME trial, which included 7020 patients with T2DM, was the first to demonstrate the cardiovascular protective effects of empagliflozin ( Subsequent trials, such as CANVAS and DECLARE-TIMI 58, have further confirmed the cardiovascular benefits of SGLT-2 inhibitors

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GLP-1 treatment may not be appropriate for patients who are pregnant, breastfeeding, planning pregnancy, or who have certain personal or family medical histories, including medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2