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In the central nervous system (CNS), GLP-1 and GLP-1R agonists are diffused into the cerebrospinal fluid (CSF) and the brain as demonstrated in rodent models (Wang et al., 2015), and increased GLP-1 concentration in the brain is thought to influence brain function in the hippocampus (Kastin et al., 2002

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doi: 10.1016/j.bcp.2022.115014 42 AsadaMRauchAShimizuHMaruyamaHMiyakiSShibamoriMet al

In conclusion, this paper study highlights the role of PDFV and VCAM-1, the precursor protein of PDFV, in OvE disease progression

Moreover, in vitro cell culture experiments have confirmed that the correlation between GLP-1RA and pancreatic cancer may be related to its ability to induce phenotypic transformation of pancreatic exocrine cells into pancreatic endocrine cells (80, 81)