Sikiric et al., 2011
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In hypoxic conditions, HIF-1 acts as the main mediator of a series of in vivo pathophysiological responses, including angiogenesis, cell proliferation, and transcriptional induction of survival genes ( Erythropoietin (EPO) is the first protein that has been identified downstream of HIF-1 to activate erythropoiesis ( Shh signaling pathway The sonic hedgehog (Shh) signaling pathway plays an important role in endogenous neurogenesis (40)