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Connective tissue stroma separated tumor cell aggregates with an abundance of psammoma bodies (calcium deposits) and foci of necrosis and hemorrhage in the tumor parenchyma

For CDDO-methyl experiments, WT mice without AAV-TBG-Cre injections were injected intraperitoneally with 5 mg/kg of either vehicle (10%DMSO in 90% corn oil) or CDDO-methyl (MedChem Express, HY-13324) for 4 days

The figure also shows the net reaction: -ketoacid + CoASH (coenzyme A) + NAD + acyl-CoA + CO 2 + NADH + H +

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