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Glutathione can reduce tyrosinase activity in different ways: Direct inactivation of tyrosinase (the key enzyme of melanogenesis) by binding the copper-containing active site of the enzyme
By supporting cellular survival cascades, it contributes to regenerative signaling environments in experimental models
For this reason, it may take a longer time (several months) to see significant skin-lightening results when relying on oral supplements alone
PMCID: PMC2083609
Consult a dermatologist for long-term oral supplements or injectable treatments
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