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Science 374 , 10871092 (2021)

Beyond the liver, redox modulation may also contribute to metformins cardioprotective effects, particularly under conditions of mitochondrial or metabolic stress ( 3 Metformin as a cardioprotective agent: mechanisms and evidence across diverse cardiac pathologies Although widely used as a first-line therapy for type 2 diabetes, metformin exerts beneficial effects that extend well beyond glucose control

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