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Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Factors such as inflammation, reduced granulation tissue formation, neuropathy, and insufficient angiogenesis impede wound healing, and oxidative stress is a key pathogenic factor ( 2 ), activates pathways such as PKC, polyol, and hexosamine, and increases the formation of AGEs

ROS serves as a common upstream event in pathophysiological pathways such as AGE formation and protein kinase C (PKC) activation during diabetic complications

Contrary to the R -gene mediated HR-type cell death, recognition in the case of basal resistance is unspecific, as intruders are recognized based on their common molecular patterns