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In a 24-week casecontrol study of obese patients with T2DM, the liraglutide plus metformin group exhibited reductions in EAT thickness from 9.6 2.0 mm to 6.8 1.5 mm at 12 weeks and 6.2 1.5 mm at 24 weeks, whereas no significant reduction was observed in the metformin-only group [140]

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Conversely, recovering GSH levels with precursors of its synthesis, such as N-acetyl-cysteine or 2-oxothiazolidine-4-carboxylic acid, increase the protective effects

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