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While the dramatic physical transformations are widely celebrated, some patients have reported an unexpected and distressing side effect: sudden hair shedding

5 participants completed Phase 2, Round 2, but their urinary excretion of toxic metals had decreased below our cut-off and did not qualify them to continue into the rest of Phase 2

Watching for stronger side effects, avoiding alcohol or other sedating substances, staying hydrated, and following dosing instructions closely are all important steps

But it also shifts the pharmacokinetics in ways the standard titration wasn't designed for

Biological analyses were performed on serum, measuring folate, vitamin B12, homocysteine, and folate receptor-alpha autoantibodies using radioimmunoassay and mass spectrometry