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However, in a mediation analysis for kidney outcomes in the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results and Semaglutide in Subjects with Type 2 Diabetes-6 trials, only 9% and 22% of risk reduction was attributable to lower BP or glycemia, respectively, with no relationship to body weight

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Lagier J-C, Hugon P, Khelaifia S, Fournier P-E, La Scola B, Raoult D