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The engineering insight behind retatrutide is that pairing glucagon-receptor agonism with strong GLP-1 and GIP agonism lets the beneficial energy-expenditure and hepatic effects come through while the incretin activity neutralizes the unwanted glucose elevation

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Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimers disease

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