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Soon D, Kothare PA, Linnebjerg H, Park S, Yuen E, Mace KF, et al

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Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels

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In the context of constitutive HIF-2 stabilization 75 or a defective mitochondrial electron transport chain 76 , glutamine-derived -KG is reductively carboxylated through the consumption of NADPH by IDH2 to generate citrate