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When these isolated senescence cells were presented with FOXO4-DRI peptide, researchers reported that the peptide appeared to block FOXO4 proteins, allowing p53 to bind with DNA, which led to the nuclear exclusion of p53 and induction of apoptosis of the senescent Leydig cells

One study found that targeting senescent p21 high cells in adipose tissue using a senolytic cocktail, dasatinib with quercetin, alleviated insulin resistance in obesity [37]

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