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According to studies, the reduced incretin effect in patients with T2DM may be due to a decrease in the response of -cell to GIP and/or GLP-1 or a decrease in GLP secretion [15, 18, 27, 28]

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Some patients interpret severe nausea as 'the drug is finally kicking in,' but this misunderstanding can lead to dehydration, electrolyte imbalances, and reduced medication compliance

The study also showed that GHK-Cu was able to decrease the production of IL-6 and TNF-1 while increasing the activity of superoxide dismutase by blocking the activation of NFBs p65 and p38 MAPK