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The majority of apoE in plasma is produced by the liver, but macrophages are responsible for producing 5 -10% of apoE in plasma (96)

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Brain Res 668(12):7179 Wang Q, Wang PH, McLachlan C, Wong PT (2005) Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced parkinsonian rats