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PNNs are formed by aggregation of heavily glycosilated proteins (proteoglycans) and, in the cortex, are preferentially associated with GABAergic cells (Morris and Henderson, 2000)

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Certain enteric pathogens, including species of Vibrio , Escherichia, and Salmonella , promote paracellular migration across the epithelium by secreting enterotoxins which target TJ complexes and increase gut permeability (Wu et al

Oxidative stress impacts tissue damage through multiple mechanisms, including damage to cell membranes and organelles, DNA damage, protein oxidation, lipid peroxidation, inflammatory responses, and the promotion of cell apoptosis and necrosis [Citation2931]

Gehlsen KR, Hadley ME, Levine N, Ray CG, Hendrix MJC