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Fukami K, Yamagishi S, Sakai K, Kaida Y, Adachi T, Ando R, Okuda S

In fact, mammalian fast-twitch (i.e., type II) muscle fibers exposed to GSH and reactant to induce S-glutathionylation showed an increase in their sensitivity to Ca 2+ , which was abrogated by the reducing agent dithiothreitol (DTT), indicating not only modification of protein thiols, but also that glutathionylation of skeletal muscle proteins can modulate Ca 2+ sensitivity [59]

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The physiological importance of copper import is further underscored by the essential role of the standard importer SLC31A1, as evidenced by reduced cardiac copper levels in SLC31A1-deficient mice [50, 58]