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Fitch and Silver, 2008)

This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release

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However, further in-depth studies are necessary to elucidate its precise mechanisms of action in prostate diseases and to develop appropriate intervention strategies accordingly

For example, the treatment with acetyl-l-carnitine induced haeme oxygenase enzyme in rat astrocytes in a dose- and time-dependent fashion, heat shock protein 60 upregulation, and increased expression of the nuclear factor erythroid 2-related factor 2 transcription factor, a master regulator of antioxidant proteins [18]