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This is especially true for Ozempic (semaglutide) , a once-weekly injectable used to manage type 2 diabetes and reduce the risk of heart and kidney complications

Establishment of Diabetic Neuropathic Pain Model and Drug Treatment We used a single intraperitoneal injection of freshly prepared STZ at a dosage of 60 mg/kg body weight in 0.01 M of the citrate buffer, pH 4.5, to induce diabetes

This means semaglutide users often add more water (2-3mL) to keep lower doses measurable, while retatrutide users at higher doses may prefer less water (1mL) to keep injection volumes manageable

Mozaffarian D, Agarwal M, Aggarwal M, et al