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Mortality reached 684,996 deaths, with a cumulative risk of 1.49%, underscoring breast cancer as a critical public health challenge ( Table 1 ), but 24,047 deaths, translating to more than half of diagnosed patients succumbing to the disease, thus reflecting structural barriers such as poor access to mammographic screening, delayed presentation, and inadequate treatment infrastructure ( Table 1 Breast cancer incidence and mortality by world region (GLOBOCAN estimates) ( Mortality-to-incidence ratio (MIR) was calculated as (deaths incident cases) 100

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Recently, researchers developed a translational pharmacokinetic and pharmacodynamic model by integrating in vitro and in vivo data in a mechanistic and quantitative manner, which revealed a dose-dependent reduction in the cardiac amyloid burdenoccurring within 4 months at 60 mg/kg and within 10 months at 10 mg/kg