J Cell Physiol 227(12):37783786 Funding This work was supported by the National Natural Science Foundation of China (Grants 61527825, 81572184, and 81471699) and the Natural Science Foundation of Guangdong Province (Grant 2014A030313378)
doi: 10.1186/s12879-018-3335-y
In addition, while a number of the agonists in Table 1 (Families 2-5) have norleucine at Rj, or an amino acid residue, in the practice of various embodiments of this invention a number of an amino acid residues (D or L) may be used at residue Ri, including without limitation, tyrosine, phenylalanine, aspartic acid, arginine, isoleucme, serine, histidine, glycine, cysteine, methionine, tryptophan, norvaline, ornithine, S-benzyl cysteine amino acid residues
The microbiome can drive autoimmunity (through Th17 cells, molecular mimicry, and pro-inflammatory metabolites) or conversely promote tolerance and tissue repair (through SCFAs, Tregs, and neuroprotective metabolites)
MOTS-c is a mitochondrial-derived peptide