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There are three ways that higher blood glucose concentrations are bad[ref]: Damage due to osmosis: High glucose causes dehydration and excessive urination

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There are also concerns about its impact on moles and the potential long-term effects on the immune system, which remain largely unknown

It was reported that Weibull parameter could be used to predict the period before an AE occured and provided relevant insights for patient pharmacological management in clinical practice (22)