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For instance, metformin can activate SIRT1 and regulate related pathways to mitigate LPS-induced SAKI and improve renal function of HFD-/STZ-induced diabetic rats (Xu et al., 2020

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Utilizing the FAERS database for analysis, we also discovered that certain drug combinations, particularly the pairing of VPA with TMP, LEV, or OLZ, markedly heightened the risk of HE