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[1] I chose to use this terminology after learning that I was a carrier of two copies of the MTHFR gene

This is mediated by the interaction of CD47 with the inhibitory macrophage receptor, SIRP (Signal regulatory protein alpha) [166]

The two are at different levels of evidence, which is something to be aware of in practical considerations

The rationale is that under normal physiological circumstances, the decline in IGFBP-1 from its maximally stimulated overnight fasting level (34) to the level seen after food intake on a molar basis is relatively modest, and only leads to minor increases in serum free IGF-I (37, 38)

It took a while to work out what frequency works for me, and over the last couple of years I have found once a month works well for me