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The patients rapid deterioration post-medication discontinuation strongly suggests medication-related hepatotoxicity ( Comparatively, existing literature typically describes milder hepatic complications in hyperthyroid patients, often resolving quickly with appropriate antithyroid medication adjustments or discontinuation ( Limitations of this case report include the absence of drug concentration data and the lack of definitive biopsy confirmation of the hepatic pathology

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Mutant #14 exhibited the highest improvement, with a 2.3-fold increase in intracellular glutathione content and a 3.2-fold increase in concentration relative to the wild-type strain (Fig