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Creatine While creatine supplementation is generally considered to be very safe, an initial high-dose loading phase (10-30g/day for 5-10 days) often causes some gastrointestinal (GI) discomfort in users.7 The problem tends to fade after the loading phase, and, if youre patient, you can skip the loading phase altogether and just start out at a maintenance dose.5 Also, as with any supplement, its ideal to talk to your doctor before adding muscle builders of any kind to your regimen

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PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1 axis

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