A deficiency of the MTHFR enzyme is caused by mutations of the MTHFR gene (at least 40 mutations have been identified)
The traditional Mediterranean diet is characterized by a high-fat content and low carbohydrate intake, with fat contributing 35 to 45% of daily caloric intake, protein contributing 15%, and carbohydrates contributing 40 to 45%
Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wide
Beyond ferroptosis-specific genes, editing regulators of autophagy can also influence this crosstalk
This creates a toxic, excitotoxic environment in the central nervous system, leading to severe anxiety, hyper-arousal, irritability, and the notorious "3 AM wake-up" insomnia that plagues so many MCAS patients