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a combination of (i) an amount of at least one compound effective for agonizing a melanocortin-receptor selected from MC- 1 R and MC-4R, and (ii) an amount of at least one compound effective for inhibiting cAMP phosphodiesterase." Specific disclosures are only to PDE-3, -4, -7 or -8 inhibitors, and a number of specific diseases are disclosed (e.g., inflammatory bowel disease, rheumatoid arthritis, asthma, etc.), but not sexual dysfunction

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