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doi: 10.1038/s41590-020-0699-0 26 JiangD.GuoY.WangT.WangL.YanY.XiaL.et al

The concentrations achieved in vitro evidently exceeds what is achieved with oral administration, particularly for compounds with limited bioavailability, extensive metabolism, and broad tissue distribution

Clinical studies have generally shown good tolerance at recommended doses, with most adverse effects being mild and transient

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